Endocrine Abstracts

Introduction: Statins are widely used to prevent cardiovascular diseases. Nonetheless, reducing cholesterol, the main substrate for steroidogenesis, may impair cortisol production. The aim of our study was to assess the effect of high dose statin therapy on cortisol and dehydroepiandrosterone-sulphate (DHEA-S) levels in type 2 diabetes male patients.Methods: This was a single-center, prospective study, during the period march 2021 - July 2022, including ...

Introduction: Statins are widely used in primary and secondary cardiovascular prevention. They have been described to improve renal function. We aimed in this study to evaluate the effect of high dose atorvastatin therapy on renal outcome in type 2 diabetes patients.Methods: This was a single-center, prospective study, including 60 men with type 2 diabetes mellitus, aged between 40 and 65 years, statin-free, in whom the indication of a high dose statin t...

IntroductionHomeostasis model assessment for insulin resistance (HOMA-IR) is widely used as a marker of insulin resistance. However, it reminds an expensive maker requiring insulin dosage. Several studies tried to found simple alternative predictors of insulin resistance such as triglycerides to HDL-C ratio with conflicting reported findings. The aim of our study was to investigate the usefulness of the atherogenic index of plasma (AIP) and the visceral ...

Introduction: Polycystic ovary syndrome is the most common cause of anovulatory infertility in women. Anti-Mullerian Hormone (AMH) was considered a reliable marker for the diagnosis of polycystic ovary syndrome (PCOS). However, AMH level is influenced by age and body mass index. The aim of this study was to analyze the performance of the (LH x AMH)/FSH ratio in the diagnosis of PCOS in women with morbid obesity.Methods: This was a cross-sectional study i...

Introduction: Statins are used in the management of hypercholesterolemia and the prevention of cardiovascular diseases. However, by reducing cholesterol biosynthesis, steroidogenesis and particularly testosterone synthesis may be affected. The aim of our study was to assess the effect of high doses of statin therapy on testosterone levels in type 2 diabetes male patients.Methods: This was a single-center, prospective study, during the period march 2021 -...

Introduction: Statins are widely used in primary and secondary prevention of atherosclerotic cardiovascular diseases. The effects of statins on vitamin D are unclear. The reduction of cholesterol synthesis, a substrate for vitamin D synthesis and the decrease of LDL, the major carrier of vitamin D in the blood, can affect vitamin D metabolism. We aimed to evaluate the effect of high dose statin therapy on serum vitamin D levels.Methods: This was a single...

Introduction: Metabolic abnormalities are usually linked with obesity. However, a proportion of obese individuals might not be at an increased risk of metabolic complications of obesity and therefore their phenotype can be referred to as metabolically healthy obesity. The aim of our study was to evaluate the metabolic status in women with morbid obesity and to determine its association with insulin resistance.Methods: In a cross sectional study, we enrol...

Introduction: Obesity related disease complications reduce life quality and expectancy and increase health care costs. Non-alcoholic fatty liver disease (NAFLD) is one of the major complications associated with obesity and is considered to be the hepatic manifestation of the metabolic syndrome. Our objective was to determine the prevalence of the NAFLD and to identify its clinical and biological associated factors in women with morbid obesity.Methods: Th...

Background: Obesity is significantly associated to several reproductive disorders in women. However, the molecular mechanisms involved in this association are complex and still not completely understood. The aim of our study was to determine the prevalence of reproductive disturbances in a group of women with morbid obesity.Methods: We conducted a cross sectional study in 50 women with a body mass index (BMI) ≥40 kg/m2 collected in the e...

Background: Obesity is an increasingly common health problem which has been found to affect female reproductive function in several aspects. The aim of our study was to determine the ovarian ultrasound features in women with morbid obesity.Methods: We performed a cross sectional study in 50 women with a body mass index (BMI) ≥40 kg /m2 collected over a period of 6 months (October 2017–March 2018). For each woman, a sus-pubic ultraso...